In-Vitro Transcription analysis of NSSAfrom HCV-3a circulating in Pakistani patients with chronic hepatitis C and their differential response to antiviral therapy

ABSTRACT

Objective: Mutations in HCV nonstructural protein 5A [NS5A] play a vital role in virus resistance The aim of this study was to develop a correlation between NS5A mutations [genotype 3a] and virolosical response towards interferon alpha [IFN-alpha] plus ribavirin therapy