[Effect of cholestasis on Dynamin-Related Protein 1 [Drpl] gene expression in rat liver]

ABSTRACT

Background and Aim: Cholestasis is characterized by impaired bile flow, which can cause accumulation of bile acids in the liver and development of metabolic disorders, resulting in hepatocellular necrosis and apoptosis. Mitochondria are a critical cellular organelle that produces most of the cellular energy. Mitochondrial morphology varies from an interconnected filamentous network to isolated dots. This processes are called mitochondrial fission and fusion. Disrupted mitochondrial morphology has been observed in cholestatic liver disease. Dynamin related protein 1 is one of the genes involved in mitochondrial fission and plays a role in apoptosis. In this study we investigated Drpl gene expression in the liver of cholestatic rats