Punica granatum L. fruit aqueous extract suppresses reactive oxygen species-mediated p53/p65/miR-145 expressions followed by elevated levels of irs-1 in Alloxan-diabetic rats

ABSTRACT

Objective: reactive oxygen species [ROS] is an apoptosis inducer in pancreatic beta-cells that stimulates p53/p65 mediated microRNA [miR]-145 expression. Punica granatum L. [pomegranate] is an antioxidant fruit that attenuates ROS generation. This study examines the effects of pomegranate fruit aqueous extract [PGE] on the levels of ROS, p53, p65, miR-145, and its target insulin receptor substrate 1 [irs-1] mRNA in Alloxan-diabetic male Wistar rats