Antibiotic resistance trends in methicillin-resistant staphylococcus aureus isolated in Kuwait hospitals: 2011-2015
Medical Principles and Practice. 2017; 26 (5): 485-490
en En
| IMEMR
| ID: emr-190430
Biblioteca responsable:
EMRO
Objective: The aim of this study was to determine antibiotic resistance trends and carriage of staphylococcal cassette chromosome mec [SCC mec ] genetic elements in methicillinresistant Staphylococcus aureus [MRSA] isolated in Kuwait hospitals to ascertain whether they were healthcare associated [HA-MRSA] or community associated [CA-MRSA]
Materials and Methods: In total, 6,922 MRSA isolates obtained from different clinical samples were tested for resistance to antibiotics, urease production, and carriage of SCC mec elements
Results: All MRSA isolates were susceptible to linezolid, vancomycin, and teicoplanin. However, some isolates were resistant to kanamycin [2,979; 43%], ciprofloxacin [2,955; 42.7%], erythromycin and clindamycin [2,935; 42.4%], fusidic acid [2,858; 41.2%], gentamicin [2,665; 38.5%], tetracycline [2,652; 38.3%], and trimethoprim [2,324; 33.5%]. Whereas the prevalence of resistance to most antibiotics showed annual variations, those resistant to chloramphenicol and rifampicin increased from 2.6 and 0.1% to 9.6 and 1.6%, respectively, and high-level mupirocin resistance declined from 9.3% in 2011 to 3.6% in 2015. In total, 3,244 [53.9%] of the isolates carried SCC mec IV followed by SCCmec III [1,737; 28.8%] and SCC me c V [890; 14.8%]. SCC mec I [21; 0.3%] and II [79; 0.8%] occurred sporadically. A total of 3,651 [60.7%] of the isolates belonged to the CA-MRSA genotype and 2,290 isolates [38.1%] were identified as HAMRSA
Conclusion: This study demonstrates changes in antibiotic resistance patterns of MRSA over time and reinforces the value of surveillance in detecting such changes for the benefit of infection control and patient management
Materials and Methods: In total, 6,922 MRSA isolates obtained from different clinical samples were tested for resistance to antibiotics, urease production, and carriage of SCC mec elements
Results: All MRSA isolates were susceptible to linezolid, vancomycin, and teicoplanin. However, some isolates were resistant to kanamycin [2,979; 43%], ciprofloxacin [2,955; 42.7%], erythromycin and clindamycin [2,935; 42.4%], fusidic acid [2,858; 41.2%], gentamicin [2,665; 38.5%], tetracycline [2,652; 38.3%], and trimethoprim [2,324; 33.5%]. Whereas the prevalence of resistance to most antibiotics showed annual variations, those resistant to chloramphenicol and rifampicin increased from 2.6 and 0.1% to 9.6 and 1.6%, respectively, and high-level mupirocin resistance declined from 9.3% in 2011 to 3.6% in 2015. In total, 3,244 [53.9%] of the isolates carried SCC mec IV followed by SCCmec III [1,737; 28.8%] and SCC me c V [890; 14.8%]. SCC mec I [21; 0.3%] and II [79; 0.8%] occurred sporadically. A total of 3,651 [60.7%] of the isolates belonged to the CA-MRSA genotype and 2,290 isolates [38.1%] were identified as HAMRSA
Conclusion: This study demonstrates changes in antibiotic resistance patterns of MRSA over time and reinforces the value of surveillance in detecting such changes for the benefit of infection control and patient management
Buscar en Google
Índice:
IMEMR
Idioma:
En
Revista:
Med. Princ. Pract.
Año:
2017