Physically targeted intravenous polyurethane nanoparticles for controlled release of atorvastatin calcium

ABSTRACT

Background: Intravenous drug delivery is an advantageous choice for rapid administration, immediate drug effect, and avoidance of first-pass metabolism in oral drug delivery. In this study, the synthesis, formulation, and characterization of atorvastatin-loaded polyurethane [PU] nanoparticles were investigated for intravenous route of administration