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Long-term outcomes of paclitaxel-eluting versus sirolimus-eluting stent for percutaneous coronary intervention: a meta-analysis
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2017; 27 (7): 432-439
en Inglés | IMEMR | ID: emr-191032
ABSTRACT
The relative long-term efficacy and safety of sirolimus-eluting stents [SES] compared with paclitaxel-eluting stents [PES] in multiple comparative studies remains controversial. This report evaluates 29 randomized trials with 18,379 patients in whom long-term [more than 1 year] outcomes were evaluated. The primary outcomes were target lesion revascularization [TLR] and the secondary end points were death, cardiac death, myocardial infarction [MI], major adverse cardiac events [MACEs], target vessel revascularization [TVR] and stent thrombosis [ST]. In comparison with PES, SES significantly reduced the long-term risk of TLR [RR=0.68; 95% CI=0.57 to 0.80, p<0.001], TVR [RR=0.69; 95% CI= 0.60 to 0.79, p<0.001] and MACE [RR=0.82; 95% CI= 0.77 to 0.88, p<0.001], while there were no significant difference with respect to death, cardiac death, MI and ST between the two groups. SES performance was significantly better for reducing the former three outcomes and comparable for the majority of the secondary end points when compared against PES
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Índice: IMEMR (Mediterraneo Oriental) Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Revista: J. Coll. Physicians Surg. Pak. Año: 2017

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Índice: IMEMR (Mediterraneo Oriental) Tipo de estudio: Ensayo Clínico Controlado Idioma: Inglés Revista: J. Coll. Physicians Surg. Pak. Año: 2017