interaction between Trolox and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid on hypoxic pulmonary vasoconstriction in the isolated rabbit lung

ABSTRACT

Background: The mechanism of hypoxic pulmonary vasoconstriction [HPV] is still debatable. It has been proposed that reactive oxygen species [ROS] might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion exchanger in acute HPV