Sclerosing epithelioid fibrosarcoma; a case report and review of literature

ABSTRACT

Sclerosing epithelioid fibrosarcoma [SEF] is a rare subtype of Fibrosarcomaandwas first reported in 1995. This tumour is rarely encountered and can easily be mistaken by clinicians for other diagnoses. This paper reports one case of SEF and review related literature. Objectives: To determine the clinical pathologic characteristics and discuss differential diagnosis of sclerosing epithelioid fibrosarcoma [SEF]. Methods: One case of SEF was studied by clinical analysis, light microscopy and the review of the literature. Results: The patient was an adult and had a tumor located in the subcutaneous tissue of the left leg, which was painless and grew slowly. Macroscopically, it was described as nodular and non-encapsulated. The cut section was gray-white, firm to elastic in consistency. The microscopic examination showed that the round to ovoid epithelioid cells with clear or eosinophilic cytoplasm arranged in cords, nests, sheets or alveolar pattern. The stroma showed a dense hyalinized collagenous background. Conclusions: Sclerosing epithelioid fibrosarcoma is a low-grade variant of fibrosarcoma, histologically, it should be differentiated from a variety of tumors which have the epithelioid appearance and sclerosing stroma