Evaluation of hs-CRP, antioxidant markers and MDA in patients of coronary artery disease [CAD] containing non-smokers and non-diabetics

Background: The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. In the present study we assessed the association of MDA, antioxidant markers, high sensitive C - reactive protein [hs-CRP] and lipid status parameters in the patients with coronary artery disease [CAD]. Significant risk factors such as cigarette and diabet were excluded from the study. Methods: Oxidative stress parameters for example Malondialdehyde [MDA], antioxidant markers including: erythrocyte superoxide dismutase[SOD], Glutathion peroxidase [GPX], Total antioxidant capacity[TAC], The inflammation marker and serum lipid status parameters were measured in 120 subjects including 60 CAD patients with angiographically diagnosed CAD and 60 CAD-free subjects as a control group, also diabetics, smoking patients, patients with malignancy, renal and liver disease, and other disease were excluded from the study. Results: The serum MDA and hs-CRP levels were increased significantly as compared to controls. However, erythrocyte SOD, GPX activities and TAC level were reduced significantly in patients [P‹0.05 in all cases]. The levels of total cholesterol, Triglyceride, LDL-C were significantly higher and that of HDL-C was meaningfully lower than those of control [P‹0.05 in all cases]. Conclusion: The association between oxidative stress parameters, antioxidant markers, the inflammation index and lipid status parameters suggest their involvement in atherosclerosis development that may lead to CAD progression