Modulation of anxiety-like behavior in sildenafil citrate treated mice placed in an elevated plus-maze
Basic and Clinical Neuroscience. 2011; 2 (4): 53-57
en Inglés
| IMEMR
| ID: emr-191865
ABSTRACT
Introduction:
Sildenafil, a phosphodiesterase-5 [PDE5] inhibitor, may have various effects on the central nervous system via the nitric oxide [NO]-cyclic guanosine monophosphate [cGMP] pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior in mice.Methods:
Male mice were intraperitoneally [i.p.] administrated sildenafil [1, 2, or 10 mg/kg], and the control group was given the vehicle 15 min before the plus-maze test. The number of entries into the open arms of the plus-maze, the time spent in the open arms, and the total numbers of entries into the arms were recorded.Results:
The results indicated that compared to the control group, the sildenafiltreated mice spent more time in the open arms and had a greater number of entries into open arms. The total number of entries into the arms did not significantly differ between the sildenafil-treated groups and the control group.Discussion:
Acute administration of sildenafil could have anxiolytic effects on male mice. This effect might be mediated in a time-dependent manner by the NO/ cGMP/PDE5 pathway
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Índice:
IMEMR (Mediterraneo Oriental)
Idioma:
Inglés
Revista:
Basic Clin. Neurosci.
Año:
2011
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