Assessment of urinary cystatin c in TV pel diabetic children

Background: Diabetes is the disease of this century; its incidence had progressively increased in the last few years especially in young ages. Cystatin C is a single chain non glycosylated basic protein produced by all nucleated cells at a constant rate freely filtered by the renal glomernli and almost entirely reabsorbed in the proximal tubule and its level in urine increases in cases with renal tubular dysfunction. Aim: The aim of the present study was to assess the urinary Cystatm C excretion in diabetic children attending the pediatric department of the National Institute of Diabetes and Endocrinology [NIDE] in comparison with apparently healthy children with comparable age and sex

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Methods: We studied 60 children and adolescents [38 Females and 22 Males] with type 1 diabetes. They had a mean age of 13.93+/-2.92 years ranging from [10-18] years and a mean duration of 6.67+/- 3.35 years of diabetes. In addition to 30 healthy children and adolescents included as a control group, fourteen of them were females and 16 were males having a mean age of 14.731 2.13 years with the age range of [10- 18] years. All subjects were subjected to full history taking and thorough clinical examination with special emphasis on diabetic details and complications and an investigations including Microalbuminuria detected by measuring the albumin in urine by turbid metric method and urine creatinine by colorimetric measure and represented by [[A/C] ratio] also urinary Cystatin C excretion by ELISA from a morning urine sample was tested

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Results and Conclusion: High urinary Cystatin C levels were present in 41 diabetic patients and none of the control group and were positively correlated to HbAlc and microalbuminuria [MA]