Frequency of NRAS gene mutation in wild type KRAS and BRAF colorectal cancers; a single center study

ABSTRACT

Background: Incidence of colorectal cancer is increasing in countries such as Iran. Molecular biomarkers play very important role in the diagnosis, treatment, and prognosis of this cancer. Mutation in the RAS family [including KRAS and NRAS] is one of these important molecular biomarkers, which should be tested before starting treatment with anti-EGRF [Epidermal growth factor] drugs