Nanocurcumin-mediated down-regulation of telomerase via stimulating TGF beta 1 signaling pathway in hepatocellular carcinoma cells
IBJ-Iranian Biomedical Journal. 2018; 22 (3): 171-179
en Inglés
| IMEMR
| ID: emr-192466
ABSTRACT
Background:
Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and transforming growth factor- beta 1 [TGF beta 1] has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomerase expression through TGF beta 1 pathway in a hepatocellular carcinoma cell line [Huh7]
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Expresión Génica
/
Telomerasa
/
Curcumina
/
Factor de Crecimiento Transformador beta1
/
Neoplasias Hepáticas
Límite:
Animales
Idioma:
Inglés
Revista:
Iran. Biomed. J.
Año:
2018
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