Comparison of BRCA1 expression between triple-negative and luminal breast tumors

ABSTRACT

Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triplenegative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with luminal breast tumors and its association with the clinicopathologic characteristics of patients