Lung cancer with concomitant double gene mutation
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2018; 28 (1): 72-73
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| IMEMR
| ID: emr-193013
ABSTRACT
A patient presenting with concomitant epidermal growth factor receptor [EGFR] mutation and anaplastic lymphoma kinase [ALK] translocation is very rare. We report a non-small cell lung cancer [NSCLC] patient with concomitant EGFR [exon 19-del] mutation and ALK rearrangement. The positron emission tomography-computed tomography [PET-CT] scan revealed a highly metabolic mass lesion in the left lower lobe, measured 5.0 cm in the largest dimension in the S6 segment. Transbronchial lung biopsy [TBLB] showed the pathological diagnosis of invasive adenocarcinoma. Thus, the patient underwent left lower lobectomy and hilar-mediastina lymph node dissection [pT2N0M0]. The tumor harbor an ALK [D5F3 +] rearrangement and EGFR [exon 19-del] mutation. The patient initially received four cycles of chemotherapy [pemetrexed and carboplatin], and achieved partial response [PR]
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Índice:
IMEMR (Mediterraneo Oriental)
Idioma:
Inglés
Revista:
J. Coll. Physicians Surg. Pak.
Año:
2018
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