Anti-inflammatory effects of curcumin on insulin resistance index, levels of interleukin-6, C-reactive protein, and liver histology in polycystic ovary syndrome-induced rats

ABSTRACT

Objective: Curcumin protects the liver against injury and fibrosis through suppressing hepatic inflammation, attenuating hepatic oxidative stress [OS], and inhibiting hepatic stellate cells [HSCs] activation. Non-alcoholic fatty liver disease [NAFLD] and polycystic ovary syndrome [PCOS] are considered as common metabolic disorders. Low-grade chronic inflammation with different markers, such as elevated C-reactive protein [CRP] and interleukin-6 [IL-6] levels, play a crucial role in PCOS. This study aimed to evaluate the therapeutic effects of curcumin on IL-6 and CRP levels as well as insulin resistance [IR] index on liver function in PCOS rats