Aberrant promoter methylation profile of niemann-pick type C1 gene in cardiovascular disease

ABSTRACT

Background: the protein of Niemann-pick type C1 [NPC1] gene promotes the egress of cholesterol from late endosomes and lysosomes to other cellular compartments and contributes to a process known as reverse cholesterol transport. This study aimed to examine whether promoter methylation of NPC1 is associated with risk of cardiovascular disease [CVD]