Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cells
IBJ-Iranian Biomedical Journal. 2013; 17 (2): 93-100
en Inglés
| IMEMR
| ID: emr-193131
ABSTRACT
Background:
elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcription factor Nrf2, a principal inducer of anti-oxidant and phase II-related genes
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Índice:
IMEMR (Mediterraneo Oriental)
Idioma:
Inglés
Revista:
Iran. Biomed. J.
Año:
2013
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