Repeated pretreatment of morphine prevents morphine-induced amnesia: a possible involvement for dorsal hippocampal NMDA receptors

ABSTRACT

Background: learning and memory processes can be affected by morphine administration. It has been previously demonstrated that the effects of morphine depend on the timing of drug administration. In the present study, the effects of microinjections of a NMDA receptor agonist and antagonist into the CA1 regions of the dorsal hippocampi [intra CA1] on repeated pretreatment of morphine-induced prevention of morphine-induced amnesia have been investigated