Helicobacter pylori: a major causative organism for peptic ulcer and its eradication

ABSTRACT

Peptic ulcer is one of the most common diseases in the third world countries. This review illustrates the understanding of the pathogenesis of peptic ulcer. The theories and concepts regarding the onset of peptic ulcer have changed by the discovery of Helicobacter pylori. The discovery of H pylori, which proved that it plays a major role in causing ulcer. It has also been reported that H pylori has a tendency to cause non-ulcer dyspepsia and gastric carcinoma. The unique features of H pylori play an important role in the diagnosis of this infection and the establishment of diagnostic procedures for its eradication. The ideal treatment for the peptic ulcer is to focus on the relief of the pain, healing of ulcer and delay in its reoccurrence. These treatments are targeted on the cytotoxic factors and also on the enhancement of the activity of cytoprotective factors