[Evaluating the association of CCR5-d32 mutation with type 2 diabetes in Rafsanjani's patients]

ABSTRACT

Background: although type-2 mellitus diabetes is the most common type of diabetes, it's main cause yet to be identified. Chemokines and their receptors are probable effective systems on diabetes. CCR5 is a chemokine receptor playing an important role in immune responses. Studies showed that the known delta32 mutation in CCR5 gene leads to disorder in the expression and function of this receptor. Hence, this project aimed to analyze the known delta32 mutation in CCR5 chemokine receptor