Determination of some benzodiazepines using N-bromosuccinimide: part I-litrimetric methods

ABSTRACT

Diazepam, lormetazepam, chlorodemethyldiazepam and lorazepam representing 1,4-benzodiazepines are quantified using N- bromosuccinimide after being hydrolyzed in aqueous hydrochloric or sulfuric acids. The stoichiometry of the reaction is ascertained in each medium. Clobazam, a 1,5-benzodiazepine, is estimated by reaction of the intact drug in 1 9 DMF/4 M HCl with N-bromosuccinimide. The methods presented are successfully applied for the determination of the aforementioned drugs in their pharmaceutical formulations