Determination of some benzodiazepines using N-bromosuccinimide: part II: spectrophotometric methods

ABSTRACT

A spectrophotometric determination of diazepam and lormetazepam based on measuring the absorbance of the corresponding benzophenones N- bromosuccinimide reaction products is presented. The method is capable of determining hydrolyzed diazepam or lormetazepam when present in mixture with the intact drug. The methods presented are successfully applied for the determination of the aforementioned drugs in their pharmaceutical formulations