[Apoptotic effect of Kyprolis on multiple myeloma KMM-1 cells through p73-mediated induction of G1 cell cycle arrest]

ABSTRACT

Background and Aim: Since proteasome is strongly considered to be involved in the development and progression of a wide variety of hematological malignancies in particular, multiple myeloma, blockage of this hemostasis system with different types of proteasome inhibitors seems to be a promising way of treatment for multiple myeloma. In this study, we investigated the effect of Kyprolis, a new irreversible proteasome inhibitor [PI], on the survival rate of multiple myeloma -derived KMM-1 cell line