Prevalence of drug resistance in pulmonary tuberculosis
JLUMHS-Journal of the Liaquat University of Medical Health Sciences. 2008; 7 (2): 79-82
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| IMEMR
| ID: emr-197913
Biblioteca responsable:
EMRO
Objective: To determine the prevalence of primary and secondary drug resistance to first line anti-tuberculous drugs. Study Design: A hospital-based cross-sectional observational study. Place and Duration: Department of Medicine Liaquat University Hospital Hyderabad/ Jamshoro and Institute of Chest Diseases Kotri from April 2005 to March 2007
Patients and Methods: Fifty cases of Pulmonary tuberculosis [TB] randomly selected from both institutes who fulfilled the following criteria 1] Sputa showed positive smear for Acid Fast bacilli on Zeil Nelson Stain. 2] Chest x-ray showed shadow consistent with TB. A detailed history, contact with TB patients, previous use of anti-tuberculous drugs and Chest x-ray was done. Sputa of all patients were sent for detail report and culture sensitivity. Descriptive and inferential statistical analysis was performed using SPSS version 14.0
Results: Among 50 patients, 28[56%] were males and 22[44%] females, age ranged from 16-80 years [38.14 + 15.69]. All 50 [100%] patients presented with fever and cough, haemoptysis in 36 [72%], chest pain in 9[18%] and dyspnea in 11[22%] cases, anemia in 39[78%] and lymphadenopathy in 12[24%]. On chest x-ray examination, 19[38%] patients had multiple infiltrations, cavitations in 10[20%], fibrosis in 9[18%], consolidation in 5[10%], pneumothorax in 4[8%] and pleural effusion in 3[6%] cases. Sputum for AFB was positive in all cases. Twenty-one [42%] culture positive patients were of primary resistance and 29[58%] were of secondary resistance. Twenty [40%] were sensitive to five drugs, 9[18%] resistant to one drug, 11[22%] to two drugs, 7 [14%] to three drugs, 3[6%] to four drugs and none resistant to five drugs
Conclusion: In our setting, the prevalence of resistance to anti-tuberculous drugs is high and alarming. Strategy should be made for proper treatment and compliance of patients to avoid the development of drug resistance
Patients and Methods: Fifty cases of Pulmonary tuberculosis [TB] randomly selected from both institutes who fulfilled the following criteria 1] Sputa showed positive smear for Acid Fast bacilli on Zeil Nelson Stain. 2] Chest x-ray showed shadow consistent with TB. A detailed history, contact with TB patients, previous use of anti-tuberculous drugs and Chest x-ray was done. Sputa of all patients were sent for detail report and culture sensitivity. Descriptive and inferential statistical analysis was performed using SPSS version 14.0
Results: Among 50 patients, 28[56%] were males and 22[44%] females, age ranged from 16-80 years [38.14 + 15.69]. All 50 [100%] patients presented with fever and cough, haemoptysis in 36 [72%], chest pain in 9[18%] and dyspnea in 11[22%] cases, anemia in 39[78%] and lymphadenopathy in 12[24%]. On chest x-ray examination, 19[38%] patients had multiple infiltrations, cavitations in 10[20%], fibrosis in 9[18%], consolidation in 5[10%], pneumothorax in 4[8%] and pleural effusion in 3[6%] cases. Sputum for AFB was positive in all cases. Twenty-one [42%] culture positive patients were of primary resistance and 29[58%] were of secondary resistance. Twenty [40%] were sensitive to five drugs, 9[18%] resistant to one drug, 11[22%] to two drugs, 7 [14%] to three drugs, 3[6%] to four drugs and none resistant to five drugs
Conclusion: In our setting, the prevalence of resistance to anti-tuberculous drugs is high and alarming. Strategy should be made for proper treatment and compliance of patients to avoid the development of drug resistance
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Índice:
IMEMR
Tipo de estudio:
Observational_studies
/
Prevalence_studies
Idioma:
En
Revista:
J. Liaquat Univ. Med. Health Sci.
Año:
2008