[Synergistic effect of rCagA and LPS of H. pylori O2 serotype in induction of proper immune response against H. pylori]

ABSTRACT

Background: H. pylori is one of gastric bacterial infectious agents that reported from world whole. This organism is heterogen and have hyper variable regions in its genome that to cause organism escape from immune response. H. pylori cagA+ strains will report that is stimulating factor for adenocarcinoma, gastritis in infected persons. H. pylori LPS have less toxicity, mitogenicity and pyrogenicity than Entrobactericeae. In this study we investigated the LPS and rCagA senergistic effect on stimulation of Th1 immune response in mice model