Effect of aspirin administration on serum lithium levels in rabbits

ABSTRACT

Effect of aspirin administration on serum lithium levels was studied at Fatima Jinnah Medical College, Lahore. 12 rabbits were divided equally into two groups and lithium was administered to one group while the other group received aspirin with lithium on body-weight basis for 22 days. Serum lithium levels were measured on the 7th, `15th, and 22nd day. Results showed a decrease in serum lithium upon administration of aspirin with lithium. We conclude that aspirin may be administered with lithium without any significantly adverse interaction or toxicity