Oral administration of titanium dioxide nanoparticle through ovarian tissue alterations impairs mice embryonic development

ABSTRACT

Background: Titanium dioxide nanoparticle [TiO[2]NP] is commonly used in industrial products including food colorant, cosmetics, and drugs. Previous studies have shown that oral administration of TiO[2]NP can be toxic to the reproductive system, but little is known if TiO[2]NP could be able to affect the functions of the female reproductive system, in particular fertility