Evaluation of S-T resolution by streptokinase therapy in patients of myocardial infarction among the age group of more than 60 years

Objective: To evaluate the benefit and efficacy of streptokinase therapy on ST-segment elevation resolution in different types of myocardial infarction in more than 60 years age group

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Materials and Methods:This Hospital based cross sectional study was conducted at National Institute of Cardiovascular Diseases [NICVD] of Karachi, Pakistan. The study included patients more than 60 years of age having different types of myocardial infarction. Fifty patients both male and female fulfilling the inclusion criteria for thrombolytic therapy were included. Baseline ECG was recorded before streptokinase infusion and repeated at completion of infusion, at 90 minutes, day 1 and day 2. Effect of streptokinase therapy [SK] on blood pressure, CKMB, and ST-segment resolution was also evaluated at 90 minutes, day 1, and Day 2

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Results: The mean systolic blood pressure was 138.20 +/- 4.57 and 125.20 +/- 3.92 pre and post SK therapy reflecting a percentage decrease of 9.40 and highly significant [P<0.001]. The Diastolic blood pressure was decrease to 9.52% with a mean value of 84.80 +/- 2.46 and 76.80 +/- 1.89 before and after the Streptokinase therapy's, segment resolution at 90 minutes was decreased to 50.69 percent from the baseline and continued to decrease at Day-1 and Day-2 with a percentage reduction of 69.12 and 84.33% respectively. The P values were highly significant [P<0.001]

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Conclusion: Thrombolysis when given within 12 hours of the onset of symptoms, improves survival, is beneficial and effective.The magnitude of benefit is greatest when reperfusion is established early. Age itself should not be considered a contraindication for fibrinolysis