[Multicentric Castleman Disease : a case report]

ABSTRACT

Background: multicentric Castleman disease is a rare lymphoproliferative disorder of unknown origin. Castleman disease [CD] also known as angiofollicular lymph node hyperplasia, is a rare lymphoproliferative disorder with poorly understood pathophysiology. The multicentric plasma cell variant is highly associated with infection by human herpesvirus 8 [HHV8], and patients have an increased risk for the development of other HHV8-associated neoplasms, including Kaposi's sarcoma and extranodal B-cell lymphoma. The authors describe a 50-year-old woman that presented with protracted fever with diagnosis of Multicentric Castleman disease