[Evaluation of bcl-2 and Bax in Invasive-DuctaI breast carcinoma and its correlation with steroidal receptors and cellular proliferative markers using Immunohistochernistry]

ABSTRACT

Background: breast carcinoma has been regarded as the most common malignant tumors and the leading cause of death due to cancer in women. Apoptosis plays a central role in both normal cell cycle and tumor biology; it is controlled by family of related proteins including Bax and bcl-2. This study was designed to evaluate the expression of Bax and bcl-2 proteins in 46 cases of Invasive-Ductal carcinoma of breast and their correlation to the expression of ki-67, estrogen and progesterone receptors immunohistochemically