Effect of some medicinal plants on liver and kidney functions in diabetic albino rats

ABSTRACT

The present study aimed to clarify the effect of aqueous extracts of five plants [Nigella sativa, Aloe vera, Ferula assafoetida, Boswellia carterii Birdw and Commiphora myrrha] and their mixture on liver and kidney functions and protein profiles. Eighty adult male albino rats were divided into eight groups, the first served as control group, other groups were injected with alloxan [120mg/kg b.wt]. The second group served as diabetic rats, the third were treated with a mixture [0.1g/100g b.wt], the fourth was treated with Nigella sativa [0.1g/100g b.wt], the fifth was treated with Aloe vera [0.05 g/100g b.wt], the sixth was treated with Ferula assafoetida [0.1g/100g b.wt], the seventh was treated with Boswellia carterri Birdw [0.1g/100g b.wt] and the eighth group was treated with Commiphora myrrha [0.05 g/100g b.wt]. After thirty days of treatment half of each group was decapitated and the other one was left for 15 days without any additional treatment as recovery period to followup their hazards if present. The results revealed highly significant increase [p<0.01] in serum transaminases [aspartate [AST] and alanine [ALT]], alkaline phosphates [ALP], total bilirubin, urea and creatinine and recorded highly significant decrease [p<0.01] in serum total protein, albumin and globulin concentrations in the diabetic group when compared with normal rates. Otherwise, all plants extracts treated groups showed insignificant changes in the previous parameters when compared with control one. It seams, therefore that the water extracts of these plants and their mixture have protective effect against the side effects of alloxan on liver and kidney