Effect of Commiphora myrrha extract on some physiological parameters and histological changes in diabetic albino rats

ABSTRACT

The present study aimed to clarify the antidiabetic activity of Commiphora myrrha [CM] aqueous extract on thirty adult male albino rats, which were divided into two groups; the first served as a control group, the second was injected with alloxan [120mg/Kg body weight] and divided into two subgroups the first served as diabetic group, the second treated with [CM] water extract [0.05mg/100 gm bwt]. After 30 days of the treatment half of each group was sacrificed and the other half was left for other 15 days without any additional treatment [recovery period]. Our results revealed highly significant decrease [p< 0.01] in blood glucose level and highly significant increase in body weight of the diabetic rats with different histological changes in cells of islets of Langerhans. These histological and physiological changes were ameliorated in rats treated with CM. Water extract of CM has a definite hypoglycemic, hyperinsulinimic effect, on the other hand, a significant increase in body weight, beta cell number and liver glycogen contents were achieved. The results of the present study clarify the role of CM as an active antidiabetic plant and suggest a relationship between drenching CM extract and insulin production. Other of investigations want be done to detect effects of different doses and time intervals of CM in diabetic animals