Conductimetric determination of cyproheptadine, cetirizine and terbinafme hydrochlorides through the formation of ion associates with manganese and zinc thiocyanate complexes

ABSTRACT

This study was carried out to develop a conductimetic titration method for determination of cyproheptadine hydrochloride [CpCl], cetirizine dihydrochloride [CetCl2] and terbinafme hydrochloride [TerCl] with manganese and zinc thiocyanate complexes [Mn [SCN]4][2-] and [Zn [SCN]4][2-] as titrants through ion-associate complex formation. The solubility products of the formed ion-associates were determined. The method was found to be highly accurate and precise having a relative standard deviation of less than 1.0%. Also it was shown that the method could be successfully applied to assay of commercial pharmaceuticals containing the above-mentioned drugs and the results are favorably comparable to the official methods: