Prevalence and management of helicobacter pylori infection in patients with peptic ulcer disease statement of responsibility

ABSTRACT

This study included 70 patients with peptic ulcer disease. 58 patients of our studied patients have proved to have been infected with H. pylori in the biopsy specimens of the peptic ulcer site. The other 12 patients did not have H. pylori in their biopsies from ulcer sites. The infected patients with H. pylori has been divided into 2 equal groups Group [I] patients received triple therapy in the form of omeprazole, ampicillin and metronidazole. Group [2] Patients received only omeprazole. The 12 non-infected patients constituted group [3], and received also omeprazole only. Follow up endoscopy for all patients has shown much better rate of healing for peptic ulcer patients in group 1 than in group 2. Healing rate in group [3] was also still better than healing in group [2]. We can conclude from our study that H. pylori plays a definite role in pathogenesis of peptic ulcer patients and the best healing of peptic ulcer patients infected with H. pylori can be achieved by the triple therapy used in our study