clinic pathological study among Egyptian children with primary nephrotic syndrome

ABSTRACT

The study included 63 nephrotic children who performed a renal biopsy in the nephrology clinics of Alexandria University Children's Hospital between 1992 and 2002. They were 30 males and 33 females. Their age at the time of onset of the disease ranged from 6 months to 74.5 years [mean 5.8324.02 years]. Eight biopsies [12.6%] were inadequate for histological examination. The most frequent pathological diagnosis in the remaining 55 biopsies was DMP [42.9%], followed by MPGN [23.8%], FSGS [72.7%], MCNS [6.3%], and lastly, one case of CNS of Finnish type [1.6%]. Most cases were steroid resistant [76.1%] and 14.3% were steroid dependent. The percentage of steroid resistance was highest among cases with MPGN [93.3%]' whereas, was lowest [50%] among MCNS. ESRF occurred in 20.6% of cases, all of them were steroid resistant. Also, death occurred in 79% of cases