[Efficacy of Estrogen Combined with Thiothixene in reducing positive and negative symptoms of schizophrenia]

ABSTRACT

Background and Aim: Schizophrenia is a chronic disabling disorder which puts heavy burdens on societies. Available treatment methods are mostly effective on positive symptoms of the disorder. Estrogen has been focused to be studied as a potential therapeutic agent in schizophrenia according to findings such as a]a later onset of the disorder in women, b] a relative subside of symptoms during pregnancy, c] a better prognosis of the disorder in women and d] variations of symptoms along with variations of menstrual hormonal phases. As the available evidence is not conclusive, this study aimed at further investigating the efficacy of estrogen in reducing positive and negative symptoms of schizophrenia