effect of a single fraction compared to multiple fractions radiotherapy on painful bone metastases with evaluation of computed t omography bone density in osteolytic bone metastases

ABSTRACT

Background: Although radiotherapy is very effective in reducing pain in painful bone metastases, the optimum dose and fractionation schedule for the palliative irradiation of painful bone metastases is controversial. Also, the optimal dose for preventing fractures remains unknown, but a clear relationship exists between reduced bone density and increased fracture risk