Role of branched chain amino acids in hepatic encephalopathy

ABSTRACT

Introduction: Hepatic encephalopathy [HE] or portosystemic encephalopathy is a state characterized by disordered central nervous system functions because of failure of liver to detoxify nitrogenous agents originating from gut because of dysfunction of hepatocytes and portosystemic shunting. Patients with HE often present alteration of mental status varying from minor psychological abnormalities to deep coma. Multiple studies conducted worldwide suggest that the branched-chain amino acids [BCAAs] leucine, isoleucine, and valine may be useful in improving survival and reducing morbidity in patients with HE