CD10 expression in ameloblastoma variants

ABSTRACT

Although benign ameloblastomas tend to behave aggressively with a high rate of recurrence. CD10 expression can help in predicting the behavior of these tumors. The aim of this study was to determine CD10 expression in variants of ameloblastomas. The data of thirty already diagnosed cases of ameloblastomas were taken. They were examined microscopically for selecting the sections with maximum epithelial content for immunohistochemical staining for CD10. A semi-quantitative scoring for determining the expression was used. In the present study, the follicular variant of ameloblastoma was the commonest [76.7%] followed by unicystic variant [13.3 %] and plexiform variant [10 %]. In the epithelial component CD10 expression was strongly positive in [76.2 %] and [80 %] showed moderate positivity. All the three cases of plexiform variant showed strong positivity. In unicystic variant [9.5%] were strongly positive and [20 %] were moderately positive. In the stromal component 50 % cases of follicular variant were strongly positive and 85.7 % were moderately positive. In the plexiform variant 25 % were strongly and 14.3 were moderately positive. In the unicystic variant strong CD10 positivity was seen in 25 % of cases. The present study concludes that all variants of ameloblastomas express CD10 positivity which may indicate their biological behavior