Improvement efficacy of Influenza nanovaccine in combination with hemokinin-1 molecular adjuvant

ABSTRACT

Background: H9N2 avian influenza viruses have the potential to become the next human pandemic threat and next generation vaccine technologies are needed. Current studies introduce nanoparticles as a proper vaccine delivery vehicle for induction of protective immunity. In this study, the efficacy of chitosan nanoparticle-based H9N2 influenza vaccine with and without hemokinin-1 [HK-1] as a molecular adjuvant to induce protective immunity against the virus was examined