Frequency of CYP1A1 gene polymorphisms in infertile men with non-obstructive azoospermia

ABSTRACT

Background and Aims: The cytochrome P450 1A1 [CYP1A1] plays a curial role in phase I metabolism of polycyclic aromatic hydrocarbons to their ultimate biologically active intermediates that have potential reproductive toxicity in men. Reproductive functions in men may be impaired by many environmental, physiologic, and genetic factors. The majority of the environmental factors are xenobiotics. Metabolic active xenobiotics exert adverse effects via covalent interactions between intermediate metabolites and cellular macromolecules such as DNA or protein