Hepatitis C virus seropositivity in repeatedly transfused thalassemia major patients

ABSTRACT

Multiple transfusions in patients of thalassemia major who are conventionally treated by a regular transfusion regimen, are at a risk of developing Transfusion Transmitted Infections [TTIs], including HCV-hepatitis. Strict criteria of safe donor selection have to be adopted in order to minimize the risk of TTIs. The present study was conducted to evaluate the seropositivity of anti-HCV antibodies in multiply transfused thalassemia major patients. A total of 75 patients of thalassemia major who had received at least 10 transfusions were tested for anti-HCV antibodies, using third generation ELISA kits. Amongst these patients, 42% were seropositive for anti-HCV antibodies. This is a high prevalence rate and calls for a critical look into the prevailing transfusion practices and adoption of stricter donor selection criteria