Treatment of central giant cell granuloma of the mandible with intralesional injection of corticosteroid

ABSTRACT

This study was carried-out to report our experience with ten cases of central giant cell granuloma [CGCG] of the mandible treated with intralesional injection of corticosteroid with special reference to the possible effect of corticosteroid on CGCG microscopically and by DNA cytophotmetry. Ten patients with CGCG of the mandible were included in this study. Triamcinolone acetonide was injected into the lesions, the injection was repeated weekly for a total of six weeks. Panoramic radiographs were obtained every three months to evaluate the healing process. Complete regression of the lesions was proved in three patients with no evidence of recurrences during a follow-up period of one year. The other seven cases needed surgical excision, which revealed significant decrease in the number [P=0.001] and size [P=0.01] of multinucleated giant cells [MNGCs]. Whereas, no differences were reported between the number of blood vessels, DNA content and ploidy pattern of MNGCs before and after the intralesional corticosteroid injection. It could be concluded that, this form of treatment may be advantageous, particularly for large lesions in order to cure or reduce the size of the lesion and thus minimize the need for extensive surgical resection that could result in functional and esthetic deficits