qualitative comparison between the inhibitory effects of salbutamol and isoxsuprine on isolated rat uterus at different stages of pregnancy

ABSTRACT

This experiment was designed to compare qualitatvely the inhibitory effects of salbutamol and isoxsuprine on isolated rat uterus at different stages of pregnancy.Twenty female white albino rats were divided equally into four groups, nonpregnant, first, second and third week pregnant groups. A standard segment of the uterus was suspended in oxygenated organ bath.Myometerial contractility was recorded by isotonic lever The effects of oxytocin, salbutamol and isoxsuprine were studied on those four groups of animals. Salbutamol appears to be more potent inhibitory drug to myometerial contractility compared to isoxsuprine in isolated preparation of the rat uterus. Particularly so during pregnancy and as pregnancy advances approaching term