[ response to Hepatitis B virus vaccine in HIV-infected patients [HIV/AIDS counseling and care center in Kermanshah]]

Background and Objective: HBV infection is preventable by effective vaccination in general population, but response to vaccine among HIV infected people seems to be low

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Methods: In this prospective study, 48 HIV position patients with anti HBs-Ab and HBs Ag had hepatitis B vaccination [0, 1, 6 months]. Anti-HBs levels were measured two months after the last dose by ELISA method. Cellular immunity was evaluated by flowcytometry

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Findings: Only 14 [29.1%] of vaccinated HIV-infected patients had positive anti-HBs titers [11 males, 3 females]. Among them, 4 [28.6%] were over 40 years and from 34 HIV positive patients who did not respond to hepatitis B vaccine, 10 [29.4%] were over 40 years old. The mean number of CD4+ T lymphocytes was 352.5 in responders and 283.9 in non-responders. 2 [17.6%] of 17 HIV positive patients with CD4+ T <200 AND 6 [31.5%] of 19 HIV positive patients with 200500 responded to hepatitis B vaccine

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Conclusion: Hepatitis B vaccination is better to be administered at the early stage of HIV infection. Conventional dose HIV vaccine is not enough for immunity. Therefore, it is recommended two-fold dose and repeated conventional dose or increasing interval administration of hepatitis B vaccine