Fixed drug eruption - most common adverse drug reaction

ABSTRACT

This study was conducted from January 2001 to January 2002 to report adverse reactions of commonly used drugs to UPPSALA/SWEDEN, through CPSP approved by Ministry of Health. Adverse drug reaction is any unintended or undesired response to a medication given at an appropriate dose [Anderson, 1987]. While reporting the adverse drug reactions, 50 cases out of 69 were diagnosed as having drug eruption [FDE]. This is one of the most common cutaneous or mucocutaneous reaction that has been reported for numerous drugs. The incidence can occur at any time without positive previous history but can be revoked by repeating the use of the same drug and also chemically related substance [Matasin, 1993]. In our study maximum cases were seen as [FDE] with vibramycin [Doxycline] next by the Septran [co-trimoxazole]. These results coincide with various other studies conducted through-out the world. This also indicates neither genetic nor racial predisposition for developing FDE. The reaction can be minimized by having a proper knowledge of the offending substance and clinical experience of the lesions