Affect of combined oral contraceptives on routine coagulation parameters

ABSTRACT

The present study was designed to estimate the coagulation parameters like fibrinogen degradation products [FDPs], fibrinogen levels, thrombin time [TT], Prothrombin time [PT] and activated partial thromboplastin time [APTT]. In this study, 40 subjects on combined oral contraceptives [COCs] with a contraceptive duration from 3-18 months and 20 normal females without hormonal contraceptives were included. Blood samples were collected for coagulation parameters in accordance with the standard protocol. FDPs and fibrinogen levels were significantly elevated whereas PT, APTT and TT were shortened in subjects using combined oral contraceptives [COCs] as compared to normal controls