Investigation of punicic acid effects on matrix metalloproteinase genes expression in bovine fibroblast like-synoviocytes as a model of osteoarthritis

ABSTRACT

Background: osteoarthritis [OA] is a progressive, age-associated disease that is characterized with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane. Considering the complications of common treatments of OA, including non-steroidal anti-inflammatory drug [NSAIDs] and corticosteroids, investigating new treatments for this disorder is crucial. Recently, the role of matrix metalloproteinases [MMPs] expression in pathogenesis of OA has attracted attention