Interleukin-1 and Keratinocyte growth factor/Fibroblast growth factor-7 gene expression in skin experimental irritant contact dermatitis mouse model treated with Aqueous extract of Trachyspermum copticum [L.] link seeds

ABSTRACT

Background: In our previous study, the extract of Trachyspermum copticum [L.] Link seeds on gene expression of IFN-alpha and TGF-beta1 in mouse model with irritant contact dermatitis [ICD], in comparison with cutaneous corticosteroids were evaluated. In that study, in addition to significantly increase of IFN-alpha and TGF-beta1 genes expression levels in skin samples of [mice with ICD] groups treated with extract in comparison to other groups, histopathologic findings showed substantial improvement of skin color, texture and thickness, and also significant increase in hair follicle number. Therefore, we have decided to study the levels of Interleukin-1 [IL-1] gene expression, which plays a major role in inflammation responses, and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 [KGF/FGF-7], which has growth effect on cells and is an important endogenous mediator of hair follicle growth and development